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phenobarbital will minimize the extent or influence of olanzapine/samidorphan by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Keep away from or Use Alternate Drug. Solid CYP3A4 inducers lessen amounts of olanzapine and samidorphan by~50% and ~seventy five% respectively.This info is only for vets. Login or create an account to realize use